Table 3.
NRTIs drug resistance mutations during the second-line antiretroviral treatment
| ID | NRTI Mutations at different time-points | |||||
|---|---|---|---|---|---|---|
| Baseline | Second-line therapy(months) | |||||
| 6 | 12 | 18 | 24 | 48 | ||
| 1001 | M41LM,E44DE,K70KR,L210 W,T215Y | – | – | – | – | K70Q, M184I |
| 1002 | None | None | None | None | None | None |
| 1007 | M41 L,D67E,K70R,M184I,T215F,K219Q | M41 L,D67E,T215F,K219Q | – | – | – | – |
| 1013 | None | – | – | – | None | |
| 1022 | D67N,K70KR,L74 V,Q151KLMQ,T215IT,K219Q | D67N,K70R,L74 V,M184I, K219Q | D67N,K70R,L74 V, M184I, K219Q | D67N,L74 V, M184I,K219Q | D67N,T69NT,L74 V,M184I, K219Q | M184 V, K219Q |
| 1026 | M41 L,T69D,V118IV, L210 W,T215Y,K219KR | – | – | – | – | None |
| 1027 | M41 L,T69ADNT,L74LV,L210 W,T215Y,K219KN | M41 L,T69D, L210 W,T215Y | M41LM,L210LW, T215DY | M41 L,T215Y | T69AT,L210LW, T215D | None |
| 1028 | None | None | None | None | None | None |
| 1029 | None | T69NT | M41 L,M184 V, L210 W,T215Y | – | – | – |
| 1031 | None | – | – | – | None | None |
| 1032 | None | – | – | None | None | – |
| 1036 | None | None | None | None | ||
| 1045 | None | None | None | _ | _ | None |
| 1049 | None | None | None | None | ||
| 1056 | None | None | None | None | None | – |
| 1062 | None | None | None | None | ||
| 1067 | None | None | – | None | – | – |
| 1068 | None | None | None | None | ||
| 1069 | M41 L,E44DE,D67N,L74 V,V118IV,M184 V,L210GW,T215Y | M41 L,D67N,L74 V,M184 V,L210GW,T215Y | – | – | – | – |
| 1076 | None | _ | _ | T69ST,M184 V | M184I | |
| 1078 | M184MV,T215FIST | – | – | – | None | – |
| 1083 | M41 L,D67NS,T69NT,K70R,T215F,K219E | – | – | – | – | M41 L, D67N, K70R, T215F, K219E |
| 1106 | T215FL | – | None | T215FIST | – | – |
| 1126 | None | – | – | None | – | None |
| 1134 | None | None | None | None | – | – |
| 1135 | None | – | None | None | – | – |
| 1136 | T215SY | – | – | – | – | T215Y |
| 1155 | M41 L,E44DE,D67N,M184I,L210 W,T215Y,K219KR | M41 L,D67N,M184I,L210 W,T215Y | – | – | – | None |
| 1161 | None | – | None | – | – | – |
| 1165 | None | None | – | – | – | – |
| 1169 | M41 L,L210LW,T215FY | M41 L,L210 W,T215Y | L210 W,T215F | M41 L,M184 V,L210 W,T215Y | – | None |
| 1170 | None | None | None | – | – | – |
| 1173 | None | – | – | None | – | – |
| 1174 | T215Y | T215Y | T215Y | None | – | – |
| 1175 | V75I | – | V75I,T215Y | – | – | – |
| 1181 | None | None | None | – | – | – |
| 1182 | None | – | – | None | – | – |
| 1195 | M41LM,L210LW,T215Y | M41 L,M184 V,T215Y | – | – | – | – |
| 1196 | M41 L,T69P,K70R,L210 W,T215FY,K219E | M41 L,T69PS,K70R,M184 V,L210 W,T215Y,K219E | – | – | – | – |
| 1197 | M184 V | M41LMV,M184 V, T215Y | – | – | – | – |
| 1198 | T215F | M41 L,T215F | – | M41LM,T215FIST | – | None |
| 1199 | None | None | – | – | – | – |
| 1202 | None | – | None | None | – | None |
| 1203 | M41 L,E44D,L210 W,T215Y | M41 L,E44DE,T69ADNT,V118I,M184 V,L210 W,T215Y | – | – | – | – |
| 1205 | M41 L,E44D,D67N,K70KR,L210 W,T215Y,K219EK | M41LM,E44DE,D67DN,K70KR,M184 V,L210 W,T215Y,K219E | D67N,K70R,M184 V,L210 W,T215Y,K219E | M41 L,D67N,K70R,M184 V,L210 W,T215Y,K219E | – | – |
NRTIs: nucleoside reverse transcriptase inhibitor; “—”: No sequence obtained; None: no drug-resistant mutation was detected; Bold font: newly acquired mutation