Table 4.
NNRTIs drug resistance mutations during the second-line antiretroviral treatment
| ID | NNRTI Mutations at different time-points | |||||
|---|---|---|---|---|---|---|
| Baseline | Second-line therapy(months) | |||||
| 6 | 12 | 18 | 24 | 48 | ||
| 1001 | V106AV,Y181C,H221Y | – | – | – | – | K103 N |
| 1002 | None | None | None | None | None | None |
| 1007 | K103 N,Y181C | K103 N,Y181C | – | – | – | – |
| 1013 | K103 N | – | – | – | K103 N | |
| 1022 | V90I,K103S,G190A | V90I,K103S,G190A | K103S,G190A | K103S,G190A | K103S,G190A | V90I, K103S, G190A |
| 1026 | V106A,V108I,F227 L | – | – | – | – | None |
| 1027 | V108I,Y181C,H221Y | V108I,Y181C,H221Y | V108I,Y181C | V108I,Y181C | V108I,Y181C | V108I, Y181CY |
| 1028 | None | None | None | None | None | None |
| 1029 | Y181C,H221HY | V106A,F227 L | ||||
| 1031 | K103 N | – | – | – | K103 N | – |
| 1032 | H221Y | – | – | None | None | – |
| 1036 | None | V179DV | ||||
| 1045 | K103 N,P225HY,F227FL | K103 N,P225HPSY,F227FL | K103 N,P225HP,F227FL | K103 N | ||
| 1049 | None | None | None | None | ||
| 1056 | None | None | None | None | None | – |
| 1062 | None | None | None | None | ||
| 1067 | None | None | – | None | – | – |
| 1068 | K103KN | None | None | None | ||
| 1069 | K103 N,Y181C,K238H | K103 N,Y181C,K238H | – | – | – | – |
| 1076 | None | None | None | None | ||
| 1078 | K101KPQT,K103KN | – | – | – | None | – |
| 1083 | Y188L | – | – | – | – | Y188L |
| 1106 | V179IL,Y188FHLY | – | None | Y188FHLY | – | – |
| 1112 | None | V106IV,G190S | ||||
| 1126 | None | – | – | None | – | – |
| 1134 | None | None | None | None | ||
| 1135 | K103KN | – | K103 N | None | – | – |
| 1136 | K103S,G190A,H221HY | – | – | – | – | K103S, G190A |
| 1155 | K101E,G190S | K101E,G190S | – | – | – | None |
| 1161 | K103 N,Y181C,H221Y | – | K103 N,Y181C | – | – | – |
| 1165 | None | None | – | – | – | – |
| 1169 | K101HKNQ,K103KN,G190A | K101H,G190A | K101H,G190A | K101H,G190A | – | None |
| 1170 | None | None | None | – | – | – |
| 1173 | None | – | – | None | – | – |
| 1174 | V106I,V108I,G190A | V106I,V108I,G190A | V108I,G190A | None | – | – |
| 1175 | K103 N | – | K103 N | – | – | – |
| 1181 | None | None | None | – | – | – |
| 1182 | G190S | – | – | None | – | – |
| 1195 | K103 N,V108I,P225H,K238 T | K103 N,V108I,P225H,K238 T | – | – | – | – |
| 1196 | V106A,F227Y,M230 L | V106A,F227Y,M230 L | – | – | – | – |
| 1197 | K101HN,V108I,Y181C,H221Y | K101HN,V108I,Y181C,H221Y | – | – | – | – |
| 1198 | Y188L | V90I,Y188L | Y188FLY | V106IV | ||
| 1199 | None | – | – | – | – | None |
| 1202 | None | – | None | None | – | None |
| 1203 | K103 N,Y181C | K103 N,Y181C | – | – | – | – |
| 1205 | V106 M,Y188C | V106 M,Y188CFLR | V106 M,Y188L | V106 M,Y188L | – | – |
NNRTIs Non-nucleoside reverse transcriptase inhibitor; “—”:No sequence obtained; None: no drug-resistant mutation was detected;