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. 2018 Sep 24;1(5):e201800039. doi: 10.26508/lsa.201800039

Figure 2. Reduced immune cell infiltration in spinal cords of HDAC11 KO compared with WT mice.

Figure 2.

(A) Representative images of H&E-stained lumbar spinal cords, isolated from WT and HDAC11 KO mice on days 0, 14, and 39 post-immunization. Scale bar, 200 μm. (B) Quantitative comparison of relative area of immune cell infiltration between WT (n = 3 per group) and HDAC11 KO (n = 3 per group) mice. (C) Representative fluorescence photomicrographs of anti-Iba1 staining to assess activated microglia/macrophages, and anti-MBP staining to assess myelin sheaths in spinal cords of EAE animals. Iba1: red; MBP: green. Scale bar, 50 μm. (D) Quantitative comparison of relative Iba-1 staining intensity between WT (n = 3 per group) and HDAC11 KO (n = 3 per group) mice. Data shown are mean ± SD, and P-values were calculated by t test, *P < 0.05.