Table 1.

Summary of BACE2 and BACE1 expression in the mouse brain.

Brain area	BACE2 expression	BACE2 expressing cell types	BACE1 expression	BACE1 expressing cell types
Hippocampus (dorsal)	−	Not found	+++	Neurons
Hippocampus (ventral CA3 and subiculum)	++	Neurons	+++	Neurons
Cortex (highest in motor and somatosensory layers 4 and 5)	+	Neurons	++	Neurons, occasional astrocytes
Thalamus	+	Neurons	+++	Neurons, occasional astrocytes
Cerebellum	+	Oligodendrocytes	++	Neurons, oligodendrocytes
Striatum	+	Oligodendrocytes	++	Oligodendrocytes
Fiber tracts	+, ++ at P16	Oligodendrocytes	++, +++ at P16	Oligodendrocytes, astrocytes
Lateral ventricle lining	+	Astrocytes	−	Not found