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. 2018 May 16;1(2):e201800070. doi: 10.26508/lsa.201800070

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© 2018 Hartmann et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 4. — Immunofluorescence of stress granule markers in HEK293 cells and patient brain. DAPI visualizes nuclei. Single confocal planes were taken. Scale bar depicts 20 μm. (A) Co-localization of poly-GR/PR with the stress granule marker G3BP1 in HEK293 cells co-transfected with RFP-STAU1 or RFP control and DPR-GFP or GFP control. Left three columns show individual channels as indicated. The fourth columns show merge with additional nuclear DAPI staining in white. Arrows indicate cytoplasmic inclusions co-labeled with G3BP1. (B) Immunofluorescence of frontal cortex of a C9orf72 patient and a healthy control case to analyze co-localization of poly-GR with stress granule components TIAR, G3BP2, YBX1, and STAU2. Arrows indicate poly-GR aggregates.

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