Appendix Table 1.

Definitions of Metabolizer Categories and Number of Participants with Each SNP Combination

	Allele copy numbers defining each SNP combination and metabolizer category
SNP	Fast		Intermediate					Slow			Not categorizeda
Ordinal level of EFV metabolismb (1 = fastest, 10 = slowest)	1	2	3	4	5	6	7	8	9	10	—	—
rs3745274 (516G>T)	0	0	0	1	0	1	0	2	1	0	1	1
rs28399499 (983T>C)	0	0	0	0	1	0	1	0	1	2	0	1
rs4803419 (15582C>T)	0	1	2	0	0	1	1	0	0	0	2	1
No. of participants in whole study by SNP combination	206	45	6	249	59	43	2	91	42	1	1	1
No. of participants in final cohort by SNP combination	69	9	2	77	22	18	0	30	14	0	1c	0d

^aTwo SNP combinations were unable to be categorized as fast, intermediate, or slow based on the previously published pharmacokinetic framework,¹⁰ and metabolizer strata were imputed for these SNP combinations.

^bBased on previously published pharmacokinetic modeling study by Holzinger et al.⁹

^cImputed as intermediate metabolize.

^dImputed as slow metabolizer.

SNP, single-nucleotide polymorphism.