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. 2018 Sep 21;1(5):e201800178. doi: 10.26508/lsa.201800178

Figure S2. Methylation dependency of SNYCRIP protein interactions.

Figure S2.

(A) Structure of SMN1 Tudor domain monomer and binding mutant used in this study (Tripsianes, 2011, PDB 4AEA). (B) Structure of PHF Tudor domain and binding mutant used in this study (Musselman, 2012, PDB 4HCZ). (C) SMN1 dimerization LUMIER experiment. LUMIER experiment testing SMN1 and PHF1 mutants against WT SMN1. Experiments undertaken in triplicate, with error bars representing highest and lowest observed values. Mann–Whitney–Wilcoxon test used to determine statistical significance. *P < 0.05. TD, Tudor domain; DD, dimerization domain.