Table 4.
Age-adjusted risk of glioma and glioblastoma by nine categories of body somatotype at ages 5, 10, 20, 30, 40, and age in 1988, using Cox proportional hazard modeling
| Tertilea | NHS (n = 201) |
HPFS (n = 138) |
||||
| Cases | Hazard ratio | 95% CI | Cases | Hazard ratio | 95% CI | |
| Glioma | ||||||
| Age 5 body diagrams | ||||||
| Low (1) | 83 | Ref | 48 | Ref | ||
| Middle (2) | 53 | 0.84 | 0.62–1.13 | 34 | 1.18 | 0.79–1.75 |
| High (3–9) | 63 | 0.65 | 0.49–0.87 | 52 | 1.08 | 0.76–1.51 |
| Age 10 body diagrams | ||||||
| Low (1) | 65 | Ref | 29 | Ref | ||
| Middle (2) (2–3) | 56 | 0.71 | 0.53–0.95 | 70 | 1.13 | 0.81–1.57 |
| High (3–9) (4–9) | 79 | 0.65 | 0.50–0.84 | 37 | 1.12 | 0.75–1.66 |
| Age 20 body diagrams | ||||||
| Low (1–2) | 76 | Ref | 47 | Ref | ||
| Middle (3) | 69 | 0.74 | 0.57–0.98 | 40 | 0.88 | 0.61–1.28 |
| High (4–9) | 56 | 0.79 | 0.59–1.06 | 49 | 0.92 | 0.65–1.31 |
| Age 30 body diagrams | ||||||
| Low (1–2) (1–3) | 50 | Ref | 64 | Ref | ||
| Middle (3) (4) | 84 | 0.65 | 0.50–0.84 | 37 | 0.76 | 0.52–1.11 |
| High (4–9) (5–9) | 65 | 0.54 | 0.41–0.72 | 35 | 0.90 | 0.61–1.33 |
| Age 40 body diagrams | ||||||
| Middle (1–3) | 92 | Ref | 37 | Ref | ||
| Middle (4) | 65 | 0.65 | 0.49–0.86 | 45 | 0.89 | 0.62–1.29 |
| High (5–9) | 44 | 0.55 | 0.40–0.76 | 55 | 0.82 | 0.58–1.16 |
| Age in 1988 body diagrams | ||||||
| Low (1–3) (1–4) | 57 | Ref | 63 | Ref | ||
| Middle (4) (5) | 66 | 0.61 | 0.46–0.81 | 46 | 0.79 | 0.56–1.12 |
| High (5–9) (6–9) | 78 | 0.52 | 0.40–0.67 | 29 | 0.82 | 0.54–1.24 |
| Tertilea | NHS (n = 123) |
HPFS (n = 100) |
||||
| Cases | Hazard Ratio | 95% CI | Cases | Hazard Ratio | 95% CI | |
| Glioblastoma | ||||||
| Age 5 body diagrams | ||||||
| Low (1) | 50 | Ref | 34 | Ref | ||
| Middle (2) | 37 | 1.01 | 0.70–1.47 | 27 | 1.41 | 0.90–2.22 |
| High (3–9) | 34 | 0.61 | 0.42–0.89 | 37 | 1.16 | 0.77–1.74 |
| Age 10 body diagrams | ||||||
| Low (1) | 37 | Ref | 17 | Ref | ||
| Middle (2) (2–3) | 40 | 0.89 | 0.62–1.28 | 56 | 1.47 | 0.99–2.18 |
| High (3 –9) (4–9) | 45 | 0.66 | 0.46–0.93 | 26 | 1.29 | 0.80–2.10 |
| Age 20 body diagrams | ||||||
| Low (1–2) | 45 | Ref | 30 | Ref | ||
| Middle (3) | 41 | 0.78 | 0.54–1.11 | 31 | 1.08 | 0.70–1.67 |
| High (4–9) | 37 | 0.91 | 0.63–1.32 | 38 | 1.14 | 0.75–1.72 |
| Age 30 body diagrams | ||||||
| Low (1–2) (1–3) | 32 | Ref | 45 | Ref | ||
| Middle (3) (4) | 49 | 0.66 | 0.47–0.92 | 27 | 0.83 | 0.53–1.29 |
| High (4–9) (5–9) | 42 | 0.61 | 0.42–0.87 | 27 | 1.05 | 0.67–1.64 |
| Age 40 body diagrams | ||||||
| Low (1–3) | 56 | Ref | 25 | Ref | ||
| Middle (4) | 38 | 0.65 | 0.45–0.93 | 34 | 1.04 | 0.67–1.60 |
| High (5–9) | 29 | 0.63 | 0.42–0.94 | 41 | 0.95 | 0.63–1.44 |
| Age in 1988 body diagrams | ||||||
| Low (1–3) (1–4) | 29 | Ref | 44 | Ref | ||
| Middle (4) (5) | 43 | 0.73 | 0.51–1.04 | 33 | 0.81 | 0.54–1.23 |
| High (5–9) (6–9) | 51 | 0.62 | 0.44–0.87 | 21 | 0.84 | 0.51–1.36 |
HPFS Health Professionals Follow-Up Study, NHS Nurses’ Health Study
a
Somatotypes categorized by tertiles for each cohort. Numbers in parentheses indicate which somatotypes fall into each tertile for NHS and HPFS