Figure 1.

Fabrication of a heparin micropatterned dual-crosslinked alginate hydrogel. a) Schematic illustration of the preparation of a heparin micropatterned dual-crosslinked alginate hydrogel. b) Photograph of a dual-crosslinked heparin/alginate hydrogel without a micropattern (left), a striped-micropatterned (250 μm) dual-crosslinked heparin/alginate hydrogel, and a dual-crosslinked alginate hydrogel without heparin. Photomicrographs of a Toluidine Blue O stained c) dual-crosslinked heparin/alginate hydrogel without a micropattern, d) stripe-micropatterned (250 μm) hydrogel and e) grid-micropatterned (200μm) dual-crosslinked heparin/alginate hydrogel.