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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2017 Sep 14;1863(12):3183–3189. doi: 10.1016/j.bbadis.2017.09.010

Figure 1. Involvement of Netrins and Semaphorins in major innate immune responses.

Figure 1

In the innate immune system, Sema4A expressed by dendritic cells (DC) and B cells is involved in the activation of T cells, induced Th1/Th17 responses as well as promoted Treg stability by inducing Foxo3a. T cells-derived Sema4D activated the humoral response of B cells and DC. In contrast, Sema4B repressed basophil activation and Th2 differentiation. Sema7A promoted inflammation by inducing the differentiation of Th1 cells. Recombinant Netrin-1 induced the expression of Th1/Th17/Th2 cytokines and regulated the bidirectional migration of T cells.