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. 2018 Nov 9;9:2535. doi: 10.3389/fimmu.2018.02535

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Copyright © 2018 Gazzinelli-Guimarães, Gazzinelli-Guimarães, Nogueira, Oliveira, Barbosa, Amorim, Cardoso, Kraemer, Caliari, Akamatsu, Ho, Jones, Weatherhead, Bottazzi, Hotez, Zhan, Bartholomeu, Russo, Bueno and Fujiwara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunization with different A. suum extracts reduces the parasite burden in infected BALB/c mice. The parasite burden was quantified by a modified Baermann apparatus after 8 days of infection in BALB/c mice. (A) Number of larvae recovered in the lung tissue; (B) Number of larvae recovered in the bronchoalveolar lavage; (C) Total number of parasite burden (Lung tissue+BAL). Statistically significant differences (p < 0.05) were plotted compared to the MPLA control group in which ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. The percentage value shown in the graph indicates the mean reduction of the parasitic burden in relation to the control group (MPLA).