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. 2018 Nov 9;9:2535. doi: 10.3389/fimmu.2018.02535

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Copyright © 2018 Gazzinelli-Guimarães, Gazzinelli-Guimarães, Nogueira, Oliveira, Barbosa, Amorim, Cardoso, Kraemer, Caliari, Akamatsu, Ho, Jones, Weatherhead, Bottazzi, Hotez, Zhan, Bartholomeu, Russo, Bueno and Fujiwara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Systemic cytokine levels induced by immunization with different A. suum extracts following infection. Upper panel Post immunization—Determination of systemic cytokine levels by ELISA after immunization with antigens. (A) IL-5. (B) IL-13. (C) TNF-α. (D) IL-6. (E) IL-2. (F) IL-10. Bottom panel Post infection—Determination of systemic cytokine levels after immunization with antigens and infection with A. suum. (G) IL-5. (H) IL-13. (I) TNF-α. (J) IL-6. (K) IL-2. (L) IL-10. Statistically significant differences (p < 0.05) were plotted compared to the controls groups PBS and PBS-ASC in which ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.