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. 2018 Nov 2;3(21):e124152. doi: 10.1172/jci.insight.124152

Figure 2. Network analysis of sera immunoprofiles predicted chemotaxis of monocytes and NK cells during ZIKV+ pregnancies.

Figure 2

Multiplex immune profiling of 37 inflammatory cytokines and 32 chemokines using serum specimens derived from 14 LA healthy pregnant women (n = 4–5/trimester) and 30 symptomatic ZIKV+ women (n = 10/trimester). (A) IPA analysis of proteins predicts the chemotaxis of major PBMC subsets: monocytes, NK cells, T cells, and B cells. (B) Correlation analysis between the total expression of inflammatory cytokines and chemokines. Viral load in ZIKV+ pregnant women and total expression of (C) inflammatory cytokines and (D) chemokines (n = 24). Correlation analyses were performed using Pearson’s r test. Solid lines, linear regression lines; dashed lines, 95% confidence interval.