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Diagrammatic representation of the role of ALMS1 in endocytosis of NKCC2. At some point of the endocytic process, the carboxyl terminus of ALMS1 (C-ALMS1) interacts with the C2-terminus of NKCC2 (C2-NKCC2) to accelerate its endocytosis and regulate NKCC2 levels at the apical surface.
