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Male, 4-month-old Tgfbr2fl/fl hHB-EGFTg/Tg and CD11b-Cre Tgfbr2fl/fl hHB-EGFTg/Tg (macrophage TGF-βRII–/–) mice were used. Macrophage TGF-βRII deletion led to significant decreases in renal fibrosis, as indicated by quantitative Sirius red staining. ***P < 0.001. n = 4 in hHB-EGFTg/Tg mice, and n = 7 in macrophage TGF-βRII–/– mice. Original magnification: ×100.
