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. 2018 Nov 2;3(21):e97677. doi: 10.1172/jci.insight.97677

Figure 7. Deficiency of iPLA2γ attenuates TBI-induced neurodegeneration and behavioral deficits.

Figure 7

(A) Representative images (of 6) showing neurodegeneration by Fluoro-Jade C (FJC) staining. (B) The number of FJC-positive cells observed in the injured cortex at 24 hours after CCI was attenuated by siRNA knock down of iPLA2γ. The white scale bar represents 30 μm. n = 6/group, *P < 0.05 vs. CCI + SC, 1-way ANOVA. The box plots depict the minimum and maximum values (whiskers), the upper and lower quartiles, and the median. The length of the box represents the interquartile range. (C) Length of time (seconds) rats remain on the balance beam apparatus before and after CCI or sham injury, n = 7/group, *P < 0.05 vs. CCI + SC, 2-way ANOVA. (D) Latency (seconds) for rats to locate a hidden (submerged) platform on post-TBI days 11–15. n = 7/group, *P < 0.05 vs. CCI + SC, 2-way ANOVA.