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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Breast Cancer Res Treat. 2017 Aug 24;166(3):937–949. doi: 10.1007/s10549-017-4469-0

Table 3.

Segregation analysis: candidate genes stratified by group

Groups Description Included genes #
Families		 Log likelihood
(95% CI)
1 + 2 Genes involved in epigenetic regulation selected from the literature and using GO terms ARID1A, BAZ1B, CHD7, CHD8, CHD9, DNMT3A, NCOR1, RIF1, TET2, CASC5, CHD5, EP400, HUWE1, KDM5B, NIPBL, NOS1, PAX5 85 1.17 (0.86, 1.56)
3 Candidate genes from whole-exome sequencing ABCA13, ANK4D30A, C15orf42, CDHR2, DGKH, DLEC1, IL17B, ITPR2, NEB, NET1, NOTCH1, PIK3C2G, PLIN4, PUM2, RBM44, RNF180, SLC22A5, SUPT3H 124 1.17 (0.94, 1.46)
4 + 5 Driver genes [30, 31] APC, CASP8, MAP3K1, ATR, CELSR1, CEP192, DNAH5, HECW1, LAMA2, LPHN2, LRP2, MDN1, NELL1, PDE4DIP, PKD1L1, RALGAPA1, SMG5, SPHKAP, SYNE1, SYNE2, TDO2, UBAP2L, UBR5, USH2A, XRN1 157 1.10 (0.89, 1.35)
1 + 2 + 4 + 5 242 1.11 (0.94, 1.32)