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. Author manuscript; available in PMC: 2018 Nov 16.
Published in final edited form as: Nature. 2018 May 16;557(7706):580–584. doi: 10.1038/s41586-018-0125-z

Extended Data Fig. 2 |. Tet−/− mice display no anatomical changes in the jejunum.

Extended Data Fig. 2 |

a, Representative images of haematoxylin and eosin-stained sections of the jejunum. b, c, Immunofluorescence analyses of sections of the jejunum of Tet2+/+ and Tet2−/− mice. b, No difference was observed between the groups in the number of apoptotic cells using the TUNEL assay (red). Nuclei of intestinal cells were visualized with DAPI (blue). c, No difference was observed in the number of apoptotic (cleaved caspase 3-positive (CC3), red) epithelial cells (pan-keratin-positive, (PanK), green) between the groups. In b, c, Jejunum sections of diphtheria-toxin-treated VDTR mice were used as a positive control. Data are representative of at least two independent experiments.