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. 2018 Oct 30;9(85):35581–35597. doi: 10.18632/oncotarget.26272

Figure 4. Effects of nasally administered MSC to cisplatin-treated mice on white matter integrity.

Figure 4

(A) Representative images of Black Gold II staining for myelin in brains of mice treated with PBS or cisplatin for two 5-day cycles followed by nasal administration of PBS or MSC as in Figure 1. (B) Black Gold II staining in cingulate cortex in animals treated with PBS, MSC, cisplatin, or cisplatin + MSC. (C) Percent area stained for Black Gold II was measured. (D) Higher magnification (20x) of myelin fibers in the cingulate cortex was (E) skeletonized, and the coherency index was measured (F) to assess the complexity of cortical myelination. Results are expressed as means ± SEM; n = 3 per group. Two-way ANOVA, Tukey post hoc: *P < 0.05.