Table 3.
PC Extracted by the PCA in All POPPY PLWH (A, n = 1073), Older POPPY PLWH Only (B, n = 699), and AGEhIV PLWH (C, n = 598) Groups
| PC (% of Variance Explained) | Meaning | Comorbidities With Correlation >0.4 (Correlation With the PC) |
|---|---|---|
| A, All POPPY PLWH (n = 1073) | ||
| 1 (6.2) | CVDs | Angina (0.66), CABG (0.66), MI (0.64), heart failure (0.59), hypertension (0.54), PVD (0.53), renal problem (0.42) |
| 2 (4.9) | STDs | Gonorrhea (0.77), syphilis (0.67), LGV (0.66), chlamydia (0.64), hepatitis C (0.40) |
| 3 (3.9) | Mental health | Depression (0.79), anxiety (0.58), panic attacks (0.50) |
| 4 (3.5) | Cancers | Hematological cancer (0.75), skin cancer (0.64), solid organ cancer (0.49) |
| 5 (3.1) | Metabolic | Dyslipidemia (0.71), lipodystrophy/lipoatrophy (0.57), hypertension (0.44) |
| 6 (2.8) | Chest and other infections | CMV (0.49), pneumonia (0.49), dizziness/vertigo (0.44), asthma/bronchitis/COPD (0.42), chest infection (0.41) |
| B, Older POPPY PLWH (n = 699) | ||
| 1 (5.7) | CVDs | Angina (0.67), heart failure (0.65), PVD (0.62), CABG (0.58), MI (0.57), hypertension (0.54), renal problems (0.44) |
| 2 (5.0) | STDs | Gonorrhea (0.74), LGV (0.72), syphilis (0.69), chlamydia (0.63), hepatitis C (0.46) |
| 3 (4.1) | Mental health and asthma | Depression (0.79), anxiety (0.58), panic attacks (0.50), asthma/bronchitis/COPD (0.45), dizziness/vertigo (0.40) |
| 4 (3.7) | Cancers | Hematological cancer (0.78), skin cancer (0.64), solid organ cancer (0.54) |
| 5 (3.3) | Metabolic | Dyslipidemia (0.71), lipodystrophy/lipoatrophy (0.43) |
| 6 (3.0) | Other | Hypothyroidism (0.46), other AIDS events (0.46) |
| C, AGEhIV PLWH (n = 598) | ||
| 1 (9.7) | CVDs | Dyslipidemia (0.73), Hypertension (0.64), PVD (0.60), angina pectoris (0.54), MI (0.51) |
| 2 (6.2) | Chest/liver | Asthma/bronchitis/COPD (0.59), liver problems (0.55), hepatitis B (0.47), dizziness/vertigo (0.43) |
| 3 (4.9) | HIV/AIDS events | Peripheral neuropathy (0.63), candidiasis (0.62), lipodystrophy (0.53), other AIDS event (0.48) |
| 4 (4.9) | Mental health & neurological problems | Eye problem (0.64), depression (0.63), urinary incontinence (0.50), loss of consciousness (0.48), sleeping problems (0.42), dizziness/vertigo (0.40) |
| 5 (4.4) | STDs | Chlamydia (0.70), gonorrhea (0.67), syphilis (0.62) |
| 6 (4.3) | General health | Heart failure (0.88), hyperparathyroidism (0.54), vitamin D deficiency (0.48), anemia (0.45) |
For each principal component, comorbidities with a high correlation (>0.4) are reported.
Abbreviations: CABG, coronary artery bypass graft; CMV, cytomegalovirus; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; LGV, lymphogranuloma venereum; MI, myocardial infarction; PC, principal component; PLWH, people living with HIV; PCA, principal component analysis; PVD, peripheral vascular disease; STD, sexually transmitted disease.