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. 2018 Nov 13;11:8089–8098. doi: 10.2147/OTT.S180112

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© 2018 Liang et al. This work is published and licensed by Dove Medical Press Limited

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TFEB knockout significantly affect cell ability of proliferation and migration in AA-free medium.

Notes: (A) TFEB knockout was established by sgTFEB and rescued by TFEB overexpression in HCT116. (B) The level of TFEB mRNA in sgctrl, sgTFEB, and sgTFEB-TFEB cells. (C) CCK-8 was used to detect these cell proliferation in AA-free medium. (D) Images of two-dimensional colony in AA-free medium. (E) Images of transwell in AA-free medium. (F) The effect of TFEB on tumor growth in vivo animal experiment. (G and H) The expression of Ki-67 and caspase-3 in tumor. ^**P<0.01.

Abbreviations: CCK-8, Cell Counting Kit-8; TFEB, transcription factor EB.