Table 2.
Distribution of specific gravity corrected biomarkers in maternal prenatal urine collected at two time points in pregnancy
| N | % > LOD | % > Highest calibration standard | Average of two measurements | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Biomarker | Early Pregnancy |
Late Pregnancy |
Early Pregnancy1 |
Late Pregnancy2 |
Early Pregnancy1 |
Late Pregnancy2 |
Geo. Mean |
10th% | 25th% | 50th% | 75th% | 90th% | 95th% |
| MEP (ng/mL) | 361 | 347 | 100.0% | 99.7% | 0.0% | 0.0% | 233.3 | 46.5 | 108.5 | 223.6 | 490.2 | 934.7 | 1574.2 |
| MnBP (ng/mL) | 361 | 347 | 99.4% | 100.0% | 0.0% | 0.0% | 27.8 | 9.5 | 15.9 | 26.4 | 47.5 | 91.3 | 119.5 |
| MiBP (ng/mL) | 361 | 347 | 95.2% | 97.5% | 0.0% | 0.0% | 3.4 | 1.1 | 1.9 | 3.3 | 6.1 | 10.9 | 16.3 |
| MP (ug/mL) | 381 | 364 | 100.0% | 100.0% | 0.3% | 3.6% | 152.8 | 29.5 | 75.5 | 168.9 | 365.0 | 631.3 | 767.1 |
| PP (ug/mL) | 381 | 351 | 98.5% | 98.7% | 0.8% | 9.4% | 39.6 | 2.6 | 11.6 | 48.0 | 166.4 | 446.5 | 636.6 |
| BP (ug/mL) | 381 | 364 | 66.5% | 71.0% | 0.0% | 0.0% | 0.5 | 0.1 | 0.1 | 0.3 | 1.7 | 12.6 | 23.5 |
| TCS (ug/mL) | 381 | 364 | 83.5% | 88.1% | 2.4% | 1.4% | 22.4 | 1.6 | 6.0 | 20.8 | 112.1 | 363.3 | 593.2 |
| 2,4-DCP (ug/mL) | 381 | 364 | 100.0% | 100.0% | 2.6% | 4.7% | 5.8 | 1.5 | 2.3 | 3.8 | 14.6 | 47.8 | 69.3 |
| 2,5-DCP (ug/mL) | 377 | 363 | 99.7% | 100.0% | 11.1% | 11.9% | 74.5 | 6.4 | 16.3 | 68.4 | 451.3 | 859.9 | 1109.1 |
| BP3 (ug/mL) | 376 | 363 | 99.7% | 99.5% | 6.7% | 7.2% | 27.1 | 2.5 | 5.2 | 18.3 | 152.1 | 564.8 | 944.4 |
1
Mean = 13 weeks gestation
2
Mean = 26 weeks gestation
LOD = Limit of detection