Table 5.

Longitudinal association of log 2 prenatal urinary biomarker concentrations and Th cell parameters at various ages, with p-values for age interaction

	Thl:Th2 cell ratio				Th1%				Th2%
Biomarker	Crude Percent difference (95% CI)	Demographically adiusred1 Percent difference (95% CI)	Fully adjusted2 Percent difference (95% CI)	p- int	Crude Percent difference (95% CI)	Demographically adiusred1 Percent difference (95% CI)	Fully adjusted3 Percent difference (95% CI)	p- int	Crude Percent difference (95% CI)	Demographically adjusted1 Percent difference (95% CI)	Fully adjusted4 Percent difference (95% CI)	p- int
	n=341–362	n=309–329	n=304–306		n=341–362	n=309–329	n=304–306		n=341–362	n=309–329	n=304–306
MEP	3.18 (−1.59, 8.17)	2.25 (−2.38, 7.10)	3.48 (−1.35, 8.54)	0.37	−0.07 (−3.53, 3.52)	0.06 (−3.49, 3.73)	1.76 (−1.97, 5.63)	0.16	−3.21 (−7.25, 1.00)	−2.17 (−6.16, 1.99)	−2.36 (−6.90, 2.41)	0.96
MnBP	−5.58 (−11.40, 0.63)#	−5.75 (−11.90, 0.82)#	−2.92 (−10.16, 4.90)	0.01	0.83 (−4.70, 6.69)	2.53 (−3.10, 8.49)	5.89 (−0.90, 13.15)#	0.29	6.54 (0.53, 12.91)*	8.50 (1.90, 15.52)*	10.40 (3.37, 17.92)**	0.02
MiBP	−6.70 (−11.58, −1.54)*	−6.33 (−11.13, −1.27)*	−5.28 (−10.56, 0.31)#	0.31	−2.82 (−7.01, 1.55)	−1.01 (−4.64, 2.76)	0.38 (−3.73, 4.66)	0.89	4.14 (−0.94, 9.49)	5.71 (0.55, 11.12)*	2.50 (−2.96, 8.25)	0.51
MP	1.07 (−3.17, 5.50)	1.45 (−2.81, 5.91)	1.85 (−2.31, 6.19)	0.80	−4.13 (−7.32, −0.82)*	−3.54 (−6.78, −0.18)*	−3.35 (−6.58, −0.02)*	0.32	−5.17 (−8.96, −1.23)*	−4.84 (−8.76, −0.74)*	−4.45 (−8.77, 0.08)#	0.62
PP	−1.01 (−3.73, 1.79)	−0.22 (−3.01, 2.65)	0.18 (−2.74, 3.19)	0.49	−1.76 (−3.83, 0.36)	−0.59 (−2.56, 1.41)	1.11 (−1.70, 3.99)	0.39	−0.76 (−3.14, 1.67)	−0.32 (−2.98, 2.41)	2.17 (−1.79, 6.28)	0.65
TCS	1.51 (−1.24, 4.33)	1.59 (−1.22, 4.47)	2.33 (−0.56, 5.30)	0.79	0.16 (−1.97, 2.33)	0.97 (−1.16, 3.14)	0.96 (−1.22, 3.20)	0.96	−1.45 (−3.88, 1.05)	−0.76 (−3.32, 1.86)	−1.39 (−3.96, 1.24)	0.64
2,4-DCP	1.61 (−2.79, 6.21)	0.37 (−3.83, 4.74)	0.29 (−4.01, 4.80)	0.97	2.98 (−0.29, 6.37)#	2.27 (−0.96, 5.61)	2.90 (−0.38, 6.28)#	0.31	1.32 (−2.56, 5.36)	1.90 (−2.04, 6.00)	2.17 (−1.83, 6.33)	0.28
2,5-DCP	0.18 (−2.91, 3.37)	−0.59 (−3.58, 2.49)	−0.26 (−3.34, 2.91)	0.75	1.90 (−0.42, 4.26)	1.15 (−1.02, 3.37)	1.51 (−0.66, 3.72)	0.11	1.65 (−1.04, 4.42)	1.70 (−1.08, 4.56)	1.54 (−1.31, 4.47)	0.48
BP3	−0.79 (−3.24, 1.71)	−1.19 (−3.79, 1.48)	−1.41 (−4.08, 1.33)	0.85	−1.38 (−3.30, 0.57)	−1.34 (−3.25, 0.61)	−0.55 (−2.59, 1.52)	0.27	−0.58 (−2.88, 1.79)	−0.09 (−2.56, 2.44)	0.50 (−2.17, 3.23)	0.43

^#p < 0.1;

^*p < 0.05;

^**p < 0.01

Separate models created for each biomarker

¹Models control for maternal age, parity, season of birth, household income as a proportion of poverty at baseline, child’s family history of asthma, active and passive smoking during pregnancy, furry pets in the home during pregnancy, and housing density during pregnancy

²Models control for maternal age, parity, season of birth, household income as a proportion of poverty at baseline, and child’s family history of asthma, active and passive smoking during pregnancy, furry pets in the home during pregnancy, housing density during pregnancy, mono-isobutyl phthalate, mono-n-butyl phthalate, triclosan

³Models control for maternal age, parity, season of birth, household income as a proportion o f poverty at baseline, and child’s family history of asthma, active and passive smoking during pregnancy, furry pets in the home during pregnancy, housing density during pregnancy, methyl paraben, the sum of di(2-ethylhexyl) phthalate m etabolites, 2,4-dichlorophenol [Regressions of 2,5-dichlorophenol did not control for 2,4-dichlorophenol due to high collinearity.]

⁴Models control for maternal age, parity, season of birth, household income as a proportion of poverty at baseline, and child’s family history of asthma, active and passive smoking during pregnancy, furry pets in the home during pregnancy, housing density during pregnancy, mono-n-butyl phthalate, methyl paraben, monoethyl phthalate