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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Pharmacol Res. 2018 Oct 28;137:252–258. doi: 10.1016/j.phrs.2018.10.026

Figure 2. Left ventricular remodeling following MI and potential therapeutic effects of MMP-12.

Figure 2.

Following MI, inflammatory cells in the left ventricle clear dead myocytes and release matrix metalloproteinases (MMPs) that degrade the extracellular matrix (ECM), leading to wall thinning and LV dysfunction. MMP-12 may be beneficial after MI by preventing excessive inflammation while promoting more efficient removal of dead cells, decreasing other MMPs, and preserving ECM integrity.