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MMP-12 inhibitor treatment worsens MI day 7 LV geometry and physiology.Adapted from (8).
| MI day 7 Saline (vs day 0 no MI) |
MI day 7 MMP-12 inhibitor (vs day 0 no MI and Ml day 7 MI Saline) |
|
|---|---|---|
| Infarct wall thickness (mm) | ↓ | ↓↓ |
| End diastolic volume (μL_) | ↑ | ↑↑ |
| End systolic volume (μL) | ↑ | ↑↑ |
| Ejection fraction (%) | ↓ | ↓↓ |
| Remodeling index (end diastolic volume/ LV mass) | ↑ | ↑↑ |
