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. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Small. 2018 May 7;14(23):e1703915. doi: 10.1002/smll.201703915

Figure 3: — C57BL/6 mice were exposed to 2.0 mg/kg bolus doses of SWNCTs delivered by one-time oropharyngeal aspiration. Animals were euthanized after 21 d, and BALF was collected to determine (A) TGF-β1 and (B) PDGF-AA levels. (C) Assessment of total collagen content by a Sircol kit (Biocolor Ltd., Carrickfergus, UK). *p < 0.05 compared to control. (D) Collagen deposition in the lung was assessed by staining lung slices with Masson’s trichrome. Collagen is stained blue in the images viewed under 100× magnification. Animals exposed to quartz (SiO₂) served as a positive control.

Figure 3: — C57BL/6 mice were exposed to 2.0 mg/kg bolus doses of SWNCTs delivered by one-time oropharyngeal aspiration. Animals were euthanized after 21 d, and BALF was collected to determine (A) TGF-β1 and (B) PDGF-AA levels. (C) Assessment of total collagen content by a Sircol kit (Biocolor Ltd., Carrickfergus, UK). *p < 0.05 compared to control. (D) Collagen deposition in the lung was assessed by staining lung slices with Masson’s trichrome. Collagen is stained blue in the images viewed under 100× magnification. Animals exposed to quartz (SiO₂) served as a positive control.