Table 4. Characteristics of IgAN patients with the highest and the lowest levels of renal miR-148b.
| Variables | IgAN- lowest levels of renal miR-148b, n=10 | IgAN- highest levels of renal miR-148b, n=10 | P-value |
|---|---|---|---|
| Age, years | 40 ± 12 | 35 ± 9 | 0.28 |
| Men, number (%) | 6 (60) | 5 (50) | 1.00 |
| MAP, mmHg | 111 ± 10 | 97 ± 8 | 0.003 |
| Serum creatinine, μmol/l | 93 ± 27 | 92 ± 28 | 0.95 |
| eGFR, ml/min/1.73 m2 | 83 ± 20 | 86 ± 29 | 0.81 |
| 24-h urinary protein, g | 1.11 (0.39–2.72) | 1.42 (0.68–3.01) | 0.27 |
| Renal megalin mRNA/18S | 0.82 (0.13–1.33) | 0.04 (0.02–0.11) | 0.002 |
| Oxford classification | |||
| M0/M1, number | 5/5 | 9/1 | - |
| E0/E1, number | 7/3 | 7/3 | - |
| S0/S1, number | 4/6 | 2/8 | - |
| T0/T1/T2, number | 7/1/2 | 7/2/1 | - |
Values are displayed as absolute numbers and percentages for gender and Oxford classification MEST scores, and mean ± S.D. or median (lower and upper quartiles) for all other variables. Renal megalin mRNA was measured by qPCR and normalized to 18S.