Table 2. Results of the selected biochemical variables in control women (n = 50) and in breast cancer (BC) patients (n = 150) pre- and post-radiotherapy (RT).
Results are shown as means and SD (in parenthesis).
| Variable | Control Group |
BC Pre-RT |
BC Post-RT |
|---|---|---|---|
| Pyruvate (μM) | 23.81 (12.07) | 58.20 (19.60) c | 74.65 (28.61) c,f |
| Lactate (μM) | 559.46 (62.55) | 466.14 (58.37) c | 548.27 (112.71) f |
| Alanine (μM) | 199.99 (66.81) | 148.97 (50.60) c | 211.01 (82.59) f |
| Hydroxybutyrate (μM) | 24.18 (18.07) | 22.20 (22.68) | 24.72 (21.92) |
| Valine (μM) | 121.68 (45.37) | 69.32 (23.38) c | 125.03 (72.95) f |
| Leucine (μM) | 68.23 (26.03) | 28.85 (11.04) c | 59.95 (38.09) f |
| Isoleucine (μM) | 32.77 (15.91) | 10.81 (5.41) c | 25.09 (18.97) a,f |
| Proline (μM) | 93.37 (29.73) | 42.99 (19.43) c | 78.44 (52.87) f |
| Malonyl Coenzyme A (μM) | 1.60 (0.31) | 1.08 (0.33) c | 1.38 (0.43) a,f |
| Glycine (μM) | 135.40 (43.91) | 78.12 (27.65) c | 106.46 (40.34) b,f |
| Succinate (μM) | 13.79 (4.20) | 8.54 (1.97) c | 11.14 (2.82) c,f |
| Fumarate (μM) | 0.37 (0.17) | 0.34 (0.17) | 0.51 (0.27) b,f |
| Serine (μM) | 56.51 (20.88) | 14.98 (14.23) c | 35.71 (30.43) c,f |
| Oxaloacetate (μM) | 26.56 (7.32) | 31.62 (13.16) a | 35.91 (11.72) c |
| Malate (μM) | 1.58 (0.76) | 1.54 (0.87) | 2.14 (1.10) a,e |
| Aspartate (μM) | 2.07 (0.91) | 14.96 (4.95) c | 16.01 (6.42) c,e |
| Ketoglutarate (μM) | 7.48 (9.45) | 3.44 (1.62) c | 4.30 (2.04) c,e |
| Glutamate (μM) | 135.47 (45.77) | 47.60 (22.25) c | 51.48 (22.75) c |
| Aconitate (μM) | 0.12 (0.05) | 0.69 (0.62) c | 0.55 (0.32) c,d |
| Citrate (μM) | 33.13 (5.86) | 43.61 (8.78) c | 54.07 (13.19) c,f |
| Glutamine (μM) | 36.73 (8.32) | 51.50 (12.43) c | 68.15 (22.57) c,f |
a P < 0.05
b P < 0.01
c P < 0.001, with respect to the control group
d P < 0.05
e P < 0.01
f P < 0.001, with respect to values Pre-RT.