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. 2018 Nov 16;13(11):e0207399. doi: 10.1371/journal.pone.0207399

Fig 1. The effects of olaparib, triapine, and cediranib combinations on the growth of subcutaneous SKOV3 xenografts in mice.

Fig 1

Athymic nude mice were inoculated s.c with SKOV3 cells. After 3 days, mice were randomly assigned to 4 groups (n = 3) and treated i.p. with vehicle, cediranib (0.75 mg/kg), the olaparib (50 mg/kg)-triapine (10 mg/kg) combination, and cediranib plus the olaparib-triapine combination daily for a continuous 6-week period (day 3 to 45). (A) Tumor size was measured every 2–3 days. Data are means ± SE. p values were determined by the Wilcoxon matched-pairs signed test compared with the control and between treatment groups. (B) Tumor tissue was excised from mice, photographed, and weighted in the end of the experiment. One largest tumor in control and cediranib groups is not shown. Data are means ± SE. p values were determined by the one-way ANOVA with the Dunnett’s multiple comparison test compared with the control. (C) Representative images of H&E-stained section of tumor tissue from respective treatment groups are shown.