Table 2.
Clinical Trial | Treatment Group (number of patients) |
Local Recurrence Rate |
p-value |
---|---|---|---|
Japanese Trial8 | Mesorectal excision alone (350) | 17.6% (5-year) | p=0.024 |
Mesorectal excision plus lateral lymph node dissection (351) | 9.8% (5-year) | ||
Dutch TME Trial11 | TME alone (701) | 11.0% (5-year) | p<0.001 |
Preoperative radiotherapy plus TME (713) | 4.6% (5-year) | ||
MRC CR07 Trial12 | TME with selective postoperative chemoradiotherapy (676) | 10.6% (3-year) | p<0.0001 |
Preoperative radiotherapy plus TME (674) | 4.4% (3-year) |
TME, total mesorectal excision