Table 2b.
Baseline characteristics of productive cough severity states, determined by SGRQ total score, in the COPDGene cohort (n=4488).
| Healthy smokers n=2717 | Productive Cough n=278 | Chronic Productive Cough n=137 | Productive Cough with Signs of Airflow Obstruction n=444 | Chronic Productive Cough with Signs of Airflow Obstruction n=912 | |
|---|---|---|---|---|---|
| Age (years) | 58 ± 8.6 | 56.0 ± 8.3 | 56.0 ± 8.3 | 55.0 ± 7.4 | 59.0 ± 8.6 |
| Male (%)* | 52.6 | 59.4 | 58.4 | 57.9 | 63.9 |
| African American (%) | 35.1 | 53.2 | 36.5 | 48 | 26.2 |
| ≥ High school education (%)* | 89.3 | 86.7 | 91.2 | 84 | 84.6 |
| BMI (kg/m2) | 29.0 ± 5.9 | 28.5 ± 5.8 | 27.7 ± 5.9 | 29.5 ± 6.2 | 28.8 ± 6.6 |
| Obese (%) | 37.5 | 37.4 | 27.7 | 40.8 | 35.9 |
| Current smoker (%)* | 46.4 | 76.3 | 76.6 | 79.5 | 69.8 |
| Pack-years* | 36.7 ± 20.5 | 38.8 ± 20.1 | 38.6 ± 18.0 | 39.4 ± 20.6 | 51.7 ± 27.1 |
| Dust and fumes exposed (%)* | 50.8 | 59.4 | 65.7 | 65.3 | 69.1 |
| FEV1/FVC* | 78.7 ± 5.1 | 78.9 ± 5.4 | 78.4 ± 5.5 | 77.8 ± 6.6 | 62.9 ± 16.6 |
| FEV1 (liters)* | 2.8 ± 0.7 | 2.8 ± 0.7 | 3.0 ± 0.7 | 2.7 ± 0.8 | 2.1 ± 0.9 |
| FEV1% predicted* | 93.6 ± 15.2 | 94.2 ± 14.5 | 95.0 ± 15.3 | 89.1 ± 16.6 | 69.5 ± 25.5 |
| FVC (liters)* | 3.6 ± 0.9 | 3.6 ± 0.9 | 3.8 ± 0.9 | 3.5 ± 1.0 | 3.3 ± 1.1 |
| FVC% predicted* | 92.4 ± 14.6 | 93.4 ± 14.3 | 94.5 ± 15.2 | 89.5 ± 15.6 | 83.5 ± 19.0 |
| Wall area % * | 63.0 ± 2.2 | 63.5 ± 2.3 | 62.9 ± 2.3 | 63.5 ± 2.2 | 64.5 ± 2.7 |
| Pi10 (X 100)* | 364.4 ± 11.3 | 364.8 ± 10.8 | 366.9 ± 12.1 | 366.4 ± 11.7 | 369.2 ± 14.3 |
| CT defined bronchiectasis | 404(16.8) | 38(15.6) | 19(16.8) | 50(13.2) | 169(20.7) |
| Exacerbations (%)† | 5 | 5.8 | 7.3 | 15.1 | 30.4 |
Results are presented as mean ± standard deviation for continuous variables and percentage for proportions.
BMI: body mass index
FEV1: forced expiratory volume in liters during the first second.
FVC: forced vital capacity in liters.
Wall area %: (wall area/total bronchial area) x100
Pi10: square root of the wall area of an airway with an internal perimeter of 10mm.
SGRQ: St. George’s Respiratory Questionnaire.
*
p<0.001
†
p<0.05