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. Author manuscript; available in PMC: 2018 Nov 16.
Published in final edited form as: Cell Rep. 2018 May 29;23(9):2667–2677. doi: 10.1016/j.celrep.2018.04.110

Figure 7. Intrathecal AIBP reverses established cisplatin-induced allodynia.

Figure 7.

A, Male mice received 2 i.p. injections of cisplatin (2.3 mg/kg) over a period of 3 days to establish allodynia. On day 7, mice were treated with i.t. AIBP (0.5 μg/ 5 μl) or saline (5 μl). Combined data from 2 independent experiments. B, The graph presents, in a different time scale, the experiment shown in panel A. Mice were tested on day 7 (after start of cisplatin treatment), before and 2 and 4 hours after i.t. AIBP and saline. Overall numbers of animals per group were on days 0–22: n = 17 (AIBP) and 12 (saline); days 29–79: n = 8 (AIBP) and 3 (saline). Mean±SEM. *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001 (two way ANOVA with Bonferroni post-test).