Table 1.
Patient and tumor characteristics of gastric adenocarcinoma (GAC) in Discovery/Technical Tissue, Biological Tissue Validation and Plasma Pilot.
| Discovery/Technical Validation | Biological Tissue Validation | |||||||
|---|---|---|---|---|---|---|---|---|
| Cases | Buffy Coat | Normal Colona | U.S. | S. Koreab | Cases | Controls | ||
| (N=14) | (N=16) | (N=19) | Cases (N=35) | Normal Controls (N=35) | Cases (N=50) | (N=36) | (N=38) | |
| Patient Characteristics | ||||||||
| Sex of patient | ||||||||
| Male | 6 (43%) | 8 (50%) | 10 (53%) | 24 (69%) | 22 (63%) | 33 (66%) | 22 (61%) | 22 (58%) |
| Female | 8 (57%) | 8 (50%) | 9 (47%) | 11 (31%) | 13 (37%) | 17 (34%) | 14 (39%) | 16 (42%) |
| Age at Diagnosis (years) | ||||||||
| Median | 65 | 54 | 64 | 78 | 66 | 62 | 70 | 69 |
| Range | (45–86) | (48–65) | (51–80) | (35–88) | (44–88) | (38–86) | (23–88) | (42–86) |
| Tumor Characteristics | ||||||||
| Tumor Site | -- | -- | -- | -- | ||||
| GE junction | 0 (0%) | 0 (0%) | 2 (4%) | 4 (11%) | ||||
| Fundus/Cardia/Body | 8 (57%) | 18 (51%) | 14 (28%) | 24 (67%) | ||||
| Antrum/Pylorus | 5 (36%) | 16 (46%) | 31 (62%) | 5 (14%) | ||||
| Diffuse | 1 (7%) | 1 (3%) | 3 (6%) | 3 (8%) | ||||
| TNM Stagec | -- | -- | -- | -- | ||||
| 1 | 1 (7%) | 12 (34%) | 6 (12%) | 8 (22%) | ||||
| 2 | 6 (43%) | 14 (40%) | 8 (16%) | 13 (36%) | ||||
| 3 | 6 (43%) | 5 (14%) | 22 (44%) | 4 (11%) | ||||
| 4 | 1 (7%) | 4 (11%) | 14 (28%) | 11 (31%) | ||||
| Tumor Sized | -- | -- | ||||||
| ≤4 | 5 (36%) | 16 (46%) | 5 (10%) | 11 (31%) | ||||
| 4.1–7.9 | 5 (36%) | 14 (40%) | 29 (58%) | 12 (33%) | ||||
| 8–11.9 | 1 (7%) | 3 (9%) | 10 (20%) | 4 (11%) | ||||
| ≥12 cm | 3 (21%) | 2 (6%) | 6 (12%) | 9 (25%) | ||||
| Histologic Typee | -- | -- | -- | -- | ||||
| Intestinal | 9 (64%) | 25 (71%) | 31 (62%) | 17 (47%) | ||||
| Diffuse | 5 (36%) | 8 (23%) | 15 (30%) | 19 (53%) | ||||
| Mixed | 0 (0%) | 2 (6%) | 3 (6%) | - | ||||
| Undefined | 0 (0%) | 0 (0%) | 1 (2%) | - | ||||
a
Normal colon tissues were used in the Disovery/Technical Validation set to rule out sequences present in colon, as this would interfere with potential future stool application. Normal stomach tissues were tested, but were de-identified so that age/sex data could not be summarized.
b
Control samples were derived from endoscopic biopsy of histologically normal gastric mucosa synchronous to gastric adenocarcinoma.
c
TNM Stage (AJCC 7th edition)’,
d
Largest diameter,
e
Based on Lauren Classification.