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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Aug 17;134:65–78. doi: 10.1016/j.addr.2018.08.005

Figure 6.

Figure 6.

Improve the pharmacokinetics of aptamers by PEGylation. A 39-mer aptamer composing of 2’-deoxy purine and 2’-O-methyl pyrimidine was conjugated with PEG (20 kDa and 40 kDa, respectively). The resulting conjugates were administered intravenously to mice at 10 mg/kg. Pharmacokinetics profiles showed that PEGylation dramatically enhanced the half-lives of the aptamers [11].