Figure 1. RCC Incidence Rate Ratios for a doubling in KIM-1 concentration, overall and by individual characteristics.
Rate ratios were estimated using conditional logistic regression models fitted to the matched case-control sets (matching criteria: date at blood draw, date of birth, sex, country) and were further adjusted for body mass index and smoking status. The rate of RCC incidence was increased with higher concentrations of KIM-1. This association did not vary by individual characteristics or time between blood draw and RCC diagnosis. The P-values are from likelihood ratio tests of the interaction terms, which test the null hypothesis of no differences among levels of the risk factors.