Skip to main content
. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: Mol Cell. 2018 Nov 1;72(4):753–765.e6. doi: 10.1016/j.molcel.2018.09.029

Figure 1 |. UHRF1 is a multi-domain protein that ubiquitylates histone H3.

Figure 1 |

(A) Following DNA replication, UHRF1 recognizes hemi-methylated DNA sites and attaches mono-ubiquitin to Lys 14, 18, 23, and 27 on the N-terminal tail of histone H3 (Harrison et al., 2016a), to serve as a recruitment signal for DNA methyltransferase DNMT1.

(B) Domain architecture of UHRF1 and approximate domain boundaries: UBL, ubiquitin-like domain; TTD, tandem tudor domain; PHD, plant homeodomain; SRA, SET and RING finger-associated domain; RING, really interesting new gene. Previously determined functions are displayed above each domain.