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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Oct 3;1864(12):3679–3687. doi: 10.1016/j.bbadis.2018.10.002

Fig. 7.

Fig. 7.

Diagram showing the effects of Bgn on the regulation of brain plasticity and peripheral metabolism. In the brain, Bgn is involved in regulation of learning and memory operation, and seems to act on molecular systems associated with brain plasticity and metabolism. In the periphery, Bgn affects the metabolism of lipids particularly acting on the liver. The transcriptomic profiling in the hypothalamus and liver, emphasizes the role of Bgn in regulating molecular pathways involved in metabolism, immune response, and neuronal signaling. The main outcomes of the actions of Bgn in the periphery seem to center on the regulations of adiposity, lean mass, and glucose metabolism. The overall results underline the role of Bgn in connecting brain plasticity with peripheral metabolism, and the importance of Bgn in the regulation of the action of fructose. PPARA: peroxisome proliferator activator receptor alpha.