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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: Cancer Res. 2018 Sep 21;78(22):6354–6362. doi: 10.1158/0008-5472.CAN-18-0687

Figure 2. Analysis of RNA-seq from serial biopsies.

Figure 2.

A) Venn diagram depicting the overlap between differentially expressed genes in Pre-Cx, CRPC, and AER serial biopsies of 4 different VCaP xenografts. B) Unsupervised clustering of Pre-Cx, CRPC, and AER xenografts based on differential gene expression. C) Differentially expressed genes between AER and Pre-Cx xenografts that meet the stringent criteria of log2FC > 2.5 and P-Value < 1.00×10-5. D) Volcano plots depicting AR target genes (266 AR gene signature from Mendiratta et al.) (12), supplemented with a selection of DHT-responsive genes from Xu et al. (4) (upper), and all significantly differentially expressed genes (lower) in the AER vs. Pre-Cx and CRPC vs. Pre-Cx comparisons. DPP4 and AR are highlighted.