Table 2.

One-year survival probability after unrelated donor hematopoietic cell transplant by detected chromosomal aberration in patients with FA.

	With aberration		Without aberration
Chromosomal aberration	N total	Probability (95% CI)	N total	Probability (95% CI)	E Log-rank p1
A. Overall
Any aberration vs. none	16	0.25 (0.08–0.48)	57	0.46 (0.33–0.59)	0.20
B. By chromosome (presence vs. absence)
Chr1q+	6	0.17 (0.00–0.54)	67	0.43 (0.32–0.55)	0.10
Chr3q+	6	0	67	0.45 (0.33–0.57)	0.04
Chr7 deletions2	7	0.29 (0.04–0.65)	66	0.42 (0.31–0.54)	0.74
Chr13 aberration3	5	0.20 (0.00–0.62)	68	0.43 (0.31–0.54)	0.46
C. Combined
Chr1q+ or chr3q+	9	0.11 (0.00–0.38)	64	0.45 (0.33–0.58)	0.02
D. By number of affected chromosomes
1–2 chromosomes vs. no aberration	9	0.44 (0.15–0.76)	57	0.46 (0.33–0.59)	0.95
≥ 3 chromosomes vs. no aberration	7	0	57	0.46 (0.33–0.59)	0.02

¹Exact-approximation log-rank test

²Includes 2 patients with chr7p- only, 2 with chr7q- only, 2 with partial deletions in both arms, and 1 with monosomy 7

³Includes 3 copy-losses, 1 copy-gain and 1 copy-neutral loss of heterozygosity.