Table 3.

Associations of 1 Standard Deviation Increment of Plasma Galectin-3 with Carotid Atherosclerosis Measures, Atherosclerosis Risk in Communities (ARIC) Study, 1996–1998.

Difference in Overall Mean IMT per 1 SD Galectin-3 Increment
	Diff (mm)	SE	p
Model 1	0.022	0.004	<.0001
Model 2	0.015	0.004	<.0001
Model 3	0.013	0.004	0.0005
Odds Ratio for Mean Carotid IMT >75th Percentile per 1 SD Galectin-3 Increment
	OR (95% CI)		p
Model 1	1.15 (1.08–1.23)		<.0001
Model 2	1.09 (1.02–1.17)		0.02
Model 3	1.08 (1.00–1.16)		0.04
Odds Ratio for Carotid Plaque and/or Shadowing per 1 SD Galectin-3 Increment
	OR (95% CI)		p
Model 1	1.12 (1.05–1.19)		0.0004
Model 2	1.09 (1.02 – 1.17)		0.01
Model 3	1.08 (1.01 – 1.16)		0.03

1 galectin-3 Standard Deviation = 4.5 ng/ml.

CI = confidence interval; IMT = Intima-media thickness; SD = Standard Deviation; SE = Standard Error.

Model 1: Adjusted for age, race-center, and gender.

Model 2: Additional adjustment for diabetes, systolic blood pressure, total cholesterol, High density lipoprotein cholesterol, triglycerides, body mass index, use of antihypertensive medication, use of anti-inflammatory medication, use of anti-ulcer medication, use of nutritional supplements, and estimated glomerular filtration rate.

Model 3: Additional adjustment for High-sensitivity C-reactive protein (log transformed).