Table 1.
Mutation frequencies for multiple INH resistance-related genes and regulator regions
| Gene locus | Functional description | Frequency (n = 188) (%) | MDRa | mono-Rb | Types of mutations | Substitution | Deletions | SNP in susceptiblec |
|---|---|---|---|---|---|---|---|---|
| katG (Rv1908c) | Catalase-peroxidase-peroxynitritase | 86.17 | 144 | 18 | 59 | 57 | 2 | R463L |
| inhA-promoter | Promoter region | 19.15 | 34 | 2 | 6 | 6 | 0 | — |
| ahpC-oxyR (Rv2427-2428) | Regulator region | 18.62 | 33 | 2 | 11 | 11 | 0 | — |
| inhA (Rv1484) | NADH-dependent enoyl-ACP reductase | 2.66 | 5 | 0 | 2 | 2 | 0 | — |
| aphC (Rv2428) | Alkyl hydroperoxidase C | 0.53 | 1 | 0 | 1 | 1 | 0 | — |
| iniA (Rv0342) | INH-inducible gene | 4.26 | 6 | 2 | 5 | 5 | 0 | G178(.) |
| Rv1592c | Unknown | 4.26 | 7 | 1 | 5 | 5 | 0 | I322V + E321(.) |
| furA (Rv1909c) | Ferric uptake regulator | 3.72 | 5 | 2 | 5 | 5 | 0 | — |
| fabD (Rv2243) | Malonyl-CoA ACP transacylase | 2.66 | 5 | 0 | 2 | 2 | 0 | P179A |
| Rv1772 | Unknown | 2.66 | 5 | 0 | 1 | 1 | 0 | — |
| nhoA/nat (Rv3566c) | Arylamine N-acetyltransferase | 2.66 | 4 | 1 | 1 | 1 | 0 | G207R |
| efpA (Rv2846c) | Efflux protein | 2.13 | 4 | 0 | 4 | 4 | 0 | — |
| kasA (Rv2245) | β-Ketoacyl ACP synthase | 2.13 | 4 | 0 | 2 | 2 | 0 | H253Y |
| iniC (Rv0343) | INH-inducible gene | 1.60 | 3 | 0 | 3 | 3 | 0 | A21(.); P22(.) |
| fadE24 (Rv3139) | Fatty acyl-CoA dehydrogenase | 1.06 | 2 | 0 | 2 | 2 | 0 | — |
| srmR (Rv2242) | Regulatory gene | 1.06 | 2 | 0 | 2 | 2 | 0 | M323T |
| fbpC (Rv0129c) | Trehalose dimycolyl transferase | 1.06 | 2 | 0 | 2 | 2 | 0 | G158S;P237S |
| iniB (Rv0341) | INH-inducible gene | 0.53 | 1 | 0 | 1 | 1 | 0 | — |
| ndh (Rv1854c) | NADH dehydrogenase | 0.53 | 1 | 0 | 1 | 1 | 0 | — |
| Rv0340 | Unknown | 0.53 | 1 | 0 | 1 | 1 | 0 | — |
| accD6 (Rv2247) | Acetyl-CoA carboxylase | 0.00 | 0 | 0 | — | — | ||
| fabG1 (Rv1483) | 3-ketoacyl-acyl carrier protein reductase | 0.00 | 0 | 0 | — | — |
aNumber of MDR isolates
bNumber of INH mono-resistant isolates
cThese types of mutations occurred simultaneously in MDR isolates and susceptible isolates, which were not included in the frequency of INH-resistant mutations