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. 2018 Nov 16;8:16965. doi: 10.1038/s41598-018-35322-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A box-and-whisker plot of pharmacokinetic parameters, AUC_inf (a) and C_max (b) after oral administration of metformin, as a function of the OCT3 haplotype (control group, n = 20; variant group, n = 25). The horizontal lines within each box represent the median. The box edges show lower (25th) and upper (75th) quartiles. The whiskers extend from the 25th and 75th quartiles to the furthest data point within a distance of 1.5 interquartile ranges from the 25th and 75th quartiles. P-values were calculated by the Mann–Whitney test.