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. 2018 Nov 16;8:16932. doi: 10.1038/s41598-018-35237-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FLN inhibits the growth of BLBC cells more efficiently than of other breast cancer subtypes. (A) Indicated breast cell lines were treated with different concentrations of FLN for 48 hours before the cell viability was measured by MTS assay. (B) The IC₅₀s of FLN for each cell line were calculated from the growth experiment in panel-A (left) and grouped and quantified based on subtypes (right). (C) MDA-MB-231 (claudin-low), LY2 (luminal), SUM149PT (basal-like), and the untransformed mammary epithelial cells MCF-10A were treated with FLN 20 µM for 6 days for colony formation. n = 4 experiments. (D) SUM102PT cells were treated with 0.5 µM FLN and/or 0.1 µM TG101348 in soft-agar for 21 days and stained by MTT.