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. 2018 Nov 16;8:16932. doi: 10.1038/s41598-018-35237-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FLN inhibits tumor growth of a BLBC xenograft model. SUM102PT cells were transplanted into the mammary glands of nude mice. When tumors became palpable, the mice bearing the tumors were randomized to be treated with either DOX or FLN. Tumor sizes relative to those at week-0 were plotted on the left. n = 9, 8, and 4 mice in vehicle, FLN, and DOX-treated groups respectively. Inset: FLN-induced N-Ras reduction was validated in SUM102PT cells. Tumor growth rate of each mouse was calculated and plotted on the right. Data were presented as Mean ± s.e.m. The pair-wise comparison was between each treatment group and the vehicle control.