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. 2018 Nov 16;8:16953. doi: 10.1038/s41598-018-35001-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Violin plot showing the relative circRNA expression for all genes in the AmpliSeq panel (i.e. ratio circRNA/(circRNA + linearRNA). The average circRNA expression values are represented by horizontal lines. The dashed line represents the value where circRNA and linear RNA are equally expressed. The RNAse R treated sample was used as a control to evaluate the specificity of the circRNA panel (B) Read counts for the circular and linear isoforms of the genes DNAJC6, SCMH1 and PRKCB in tissue samples, blood and serum. All three genes show a dramatic increase of relative circular RNA expression in serum, indicating that the linear isoforms of DNAJC6, SCMH1 and PRKCB are virtually absent from that sample.