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. 2018 Nov 16;9:4822. doi: 10.1038/s41467-018-07215-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Transcriptome and cytokine responses to LPS in neonatal monocytes. a Principal component (PC) analysis of unstimulated versus LPS-stimulated monocytes and b Venn diagram of differentially expressed genes (LPS-stimulated samples) overlapping between age groups (FDR 5%). c Expression heatmap of cytokine genes (5 h LPS; scale = z-score) Data from same subjects as in Fig. 3, except for 1 adult and 2 preterm subjects with insufficient cells for LPS condition; d Production of cytokines following LPS stimulation (24 h, mononuclear cells) by ELISA (effect of age by two-way ANOVA; mean ± SD; n = 3 to 6 subjects per age group)