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. 2018 Nov 16;8:16939. doi: 10.1038/s41598-018-35083-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of 5-FU and VER, alone and combined, on viability and cell cycle progression in Caco-2 & HCT-116 cell lines. (a) Dose-response plots of 5-FU, VER, and 5-FU + VER on HCT-116 and Caco-2 cell lines after 72 hrs exposure, as detected by MTT assay. (b,c) DNA content-based cell cycle analysis in Caco-2 cell line treated with 10 μM 5-FU, 0.1 μM VER, & 10 μM 5-FU + 0.1 μM VER. Results represent three independent experiments performed in triplicates.