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. 2018 Nov 16;8:16923. doi: 10.1038/s41598-018-35252-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Outline of the role of Notch and Dlk gene over-expression on 3T3-L1 adipogenesis and adipocyte browning. The effects of adipogenic inductors on control 3T3-L1 preadipocytes is compared with the effects of the same adipogenic inductors on 3T3-L1 cells stably over-expressing each one of the Notch or Dlk genes. The direction (up or down) of the variations in the expression of aP2, Pparg, and several brown adipocyte and mitochondrial biogenesis markers, are shown by arrows.