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. 2018 Nov 16;8:16951. doi: 10.1038/s41598-018-34855-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Heatmaps of the top 50 differentially expressed genes. The heatmaps display the log2 fold change of the top 50 genes (up and downregulated) at 12 and 24 h after treatment. (b) GO term overrepresentation of the top up-regulated 100 genes at 12 h. (c) GO term overrepresentation of the top up-regulated 100 genes at 24 h. The size of each circle is correlated to the number of genes and the color of the nodes indicates different levels of significance for the enriched terms according to the provided key.