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. 2018 Oct 15;175(23):4338–4352. doi: 10.1111/bph.14493

Figure 7.

Figure 7

The symptoms and inflammation of DSS‐induced colitis were ameliorated in ZFP91‐deficient mice. Wild type (WT) or ZFP91 knockout (ZFP91−/−) C57BL/6 mice were fed 4% DSS dissolved in drinking water for 5 days. (A) Basal body weight changes of each group (n = 8 per group) after DSS induction of colitis. (B) Macroscopic appearances and (C) colon lengths of the mice were measured. *P < 0.05 compared with DSS‐treated WT mice. (D) Disease activity index. *P < 0.05 compared with DSS‐treated WT mice. (E) The production of inflammation‐related cytokine IL‐1β in serum was determined by ELISA. *P < 0.05 compared with DSS‐treated WT mice. (F) Histopathological changes in colon tissue were examined by H&E staining. The protein expression of IL‐1β in colon tissues was detected by immunohistochemical analysis. Original magnification: ×200. (G–I) Immunoblot analysis of lysates from colon tissue.